TEXANS 38, TITANS 14
HOUSTON - Danieal Manning and Kareem Jackson returned interceptions for touchdowns and Matt Schaub threw two TD passes.
Arian Foster had a touchdown run for the Texans (4-0), who are off to the best start in club history.
Titans quarterback Jake Locker left in the first quarter and did not return after hurting his left, nonthrowing shoulder on a hit by Glover Quin.
Matt Hasselbeck threw two touchdown passes in relief of Locker for the Titans (1-3).
CARDINALS 24, DOLPHINS 21, OT
GLENDALE, Ariz. - Jay Feely kicked a 46-yard field goal 6:31 into overtime to keep Arizona unbeaten.
The Cardinals (4-0) forced overtime when Kevin Kolb threw a 15-yard touchdown pass on fourth down to Andre Roberts with 22 seconds to play in regulation.
Two big defensive plays set up the final two Arizona scores. First, Daryl Washington sacked rookie Ryan Tannehill, whose fumble was recovered by Vonnie Holliday at the Arizona 49 and the Cardinals moved downfield to score.
Tannehill threw for 431 yards. Brian Hartline set a Dolphins record with 253 yards receiving on 12 catches.
49ERS 34, JETS 0
EAST RUTHERFORD, N.J. - Carlos Rogers returned a fumble 51 yards for a touchdown, and San Francisco ran for more than 200 yards.
Frank Gore, Kendall Hunter and backup quarterback Colin Kaepernick - on a wildcat-style option - all ran for scores as the 49ers (3-1) bounced back from a loss at Minnesota. Rather than head back to the West Coast, coach Jim Harbaugh chose to have his team stay in eastern Ohio - and it apparently helped.
The Jets (2-2) lost top wide receiver Santonio Holmes to what appeared to be a serious foot injury.
BRONCOS 37, RAIDERS 6
DENVER - Peyton Manning finished with 338 yards and three touchdown passes.
Manning opened the game by leading the Broncos on an 80-yard touchdown drive - their first opening-quarter touchdown of the season - and Denver never trailed.
The Broncos (2-2) beat the Raiders (1-3) at home for the first time since 2007.
VIKINGS 20, LIONS 13
DETROIT - Percy Harvin returned the opening kickoff 105 yards for a touchdown and Marcus Sherels scored on a punt return early in the third.
Minnesota (3-1), in first place in the NFC North, matched the number of wins it had last season. The Vikings also snapped an 11-game losing streak in the division.
The Lions (1-3) have lost three straight.
RAMS 19, SEAHAWKS 13
ST. LOUIS - Rookie Greg Zuerlein kicked four field goals, including a 58-yarder and a club record 60-yarder, and the Rams also used a fake field goal to score their only TD of the game.
The Rams (2-2) went ahead 10-7 late in the first half when a fake field goal attempt turned into a 2-yard touchdown pass from punter Johnny Hekker to Danny Amendola.
The Seahawks (2-2) lost six days after beating Green Bay when a botched call by replacement officials on the final play gave them the winning touchdown. Regular officials were back this weekend.
PATRIOTS 52, BILLS 28
ORCHARD PARK, N.Y. - Tom Brady led New England on six consecutive second-half touchdown drives to beat the Bills (2-2).
Brady finished 22 of 36 for 340 yards and three scores, and also scored on a 4-yard run in helping the Patriots (2-2) avoid their first three-game losing streak in 10 years. Stevan Ridley scored two touchdowns rushing. New England scored 35 straight points and finished with 580 total yards in overcoming a 21-7 third-quarter deficit.
The Patriots forced six turnovers, including four interceptions of Ryan Fitzpatrick passes, and three sacks.
CHARGERS 37, CHIEFS 20
KANSAS CITY, Mo. - Philip Rivers threw for 209 yards and two touchdowns, and San Diego capitalized on six turnovers.
Five of the Chiefs' turnovers came in the first half, when San Diego (3-1) raced to a 27-6 lead.
Matt Cassel threw for 251 yards and two touchdowns for Kansas City (1-3), but he also had three first-half interceptions. Jamaal Charles, who followed his big game last week at New Orleans with touchdowns rushing and receiving, fumbled twice.
PACKERS 28, SAINTS 27
GREEN BAY, Wis. - Aaron Rodgers threw a go-ahead touchdown to Jordy Nelson in the fourth quarter, and Green Bay shook off a week's worth of controversy with a rally.
With Packers fans howling about what appeared to be yet another bad call - this time by the regular officials, not the replacements - Garrett Hartley missed a 48-yard field goal attempt with just under three minutes remaining, costing the Saints a shot at the lead.
Rodgers threw for 319 yards with four touchdowns and an interception for the Packers (2-2).
Drew Brees threw for 446 yards with three touchdowns for the winless Saints (0-4).
REDSKINS 24, BUCCANEERS 22
TAMPA, Fla. - Billy Cundiff redeemed himself for a poor day kicking, booting a 41-yard field goal with 3 seconds remaining.
Cundiff missed three earlier attempts, including a 31-yarder that wound have put the Redskins (2-2) up by two scores early in the fourth quarter. He also missed twice in the first half, but was on the money after Robert Griffin III marched his team into position for the winning score over the Buccaneers (1-3).
BENGALS 27, JAGUARS 10
JACKSONVILLE, Fla. - Andy Dalton threw two touchdown passes and ran for a score.
Dalton and A.J. Green burned Jacksonville several times, including once to set up a second-quarter touchdown and again for a fourth-quarter score.
The Bengals (3-1) finished with six sacks, putting constant pressure on Blaine Gabbert and overcoming all those defensive injuries. Cincinnati played without starting cornerbacks Nate Clements and Leon Hall as well as backups Jason Allen and Dre Kirkpatrick.
The Jaguars (1-3) failed to take advantage.